17-α Hydroxyprogesterone Caproate Immunology, a Special Focus on Preterm Labor, Preeclampsia, and COVID-19
نویسندگان
چکیده
17-α hydroxyprogesterone caproate (17-OHPC) could alter the immune response and inflammation, specifically affecting risk of preterm labor preeclampsia. However, exact inflammatory effects 17-OHPC remain hard to be identified. The current literature on is limited more research needed identify these mechanistic pathways. Further, coronavirus disease 2019 (COVID-19) infection in pregnancy involves heightened response, widespread inflammation high rates Since pathogenesis labor, preeclampsia COVID-19 altered it important explore possible pregnant women with COVID-19. This commentary article will explain their implications
منابع مشابه
Prevention of Recurrent Preterm Delivery by 17 Alpha-Hydroxyprogesterone Caproate
From Wake Forest University, WinstonSalem, N.C. (P.J.M.); the National Institute of Child Health and Human Development, Bethesda, Md. (M.K., C.Y.S.); the Biostatistics Center, George Washington University, Rockville, Md. (E.T.); Wayne State University, Detroit (M.P.D.); the University of Tennessee, Memphis (B.S.); the University of Chicago, Chicago (A.H.M.); the University of Alabama, Birmingha...
متن کاملPrevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate.
BACKGROUND Women who have had a spontaneous preterm delivery are at greatly increased risk for preterm delivery in subsequent pregnancies. The results of several small trials have suggested that 17 alpha-hydroxyprogesterone caproate (17P) may reduce the risk of preterm delivery. METHODS We conducted a double-blind, placebo-controlled trial involving pregnant women with a documented history of...
متن کامل17-Hydroxyprogesterone Caproate as a Potential Therapeutic to Add to the Management of Preeclampsia
Preeclampsia (PE) is a complex disorder, occurring during the third trimester of gestation characterized by hypertension with proteinuria, increased uterine artery resistance (UARI), elevated inflammatory cytokines and endothelial dysfunction during pregnancy. 17-hydroxyprogesterone caproate (17-OHPC), a synthetic hormone called progestogen or progestin, is already approved by US Food and Drug ...
متن کاملPharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth: a case-control study.
OBJECTIVE To compare maternal genotypes between women with and without significant prolongation of pregnancy in the setting of 17-alpha hydroxyprogesterone caproate (17-P) administration for the prevention of recurrent preterm birth (PTB). DESIGN Case-control. SETTING Three tertiary-care centres across the USA. POPULATION Women (n = 99) with ≥ 1 prior singleton spontaneous PTB, receiving ...
متن کاملA Comparison between the Effects of Vaginal Suppository Progesterone vs. the Injection of 17-Alpha Hydroxyprogesterone Caproate on the Duration of Latent Phase After Controlled Threatened Preterm Labor
Background: Women with preterm labor put in an arrest phase by tocolytic therapy, are at increased risk of recurrent preterm labor. The aim of this study is to evaluate vaginal progesterone suppositories as compared to intramuscular type in order to prevent preterm labor in women with episodes of threatened preterm labor. Methods: This prospective longitudinal...
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ژورنال
عنوان ژورنال: Reproductive medicine
سال: 2022
ISSN: ['2673-3897']
DOI: https://doi.org/10.3390/reprodmed3030019